LIVER METABOLIC EFFECTS OF A HIGH-FAT LOW- CARBOHYDRATE DIET IN RATS: A STUDY UNDER DIFFERENT ENERGY CONDITIONS
نویسندگان
چکیده
The beneficial effects of high-fat, low-carbohydrate (HFLC) diets on glucose metabolismhave been questioned and its liver metabolism are not totally clear. This workaimed to evaluate the HFLC diet under different energy conditions glucosehomeostasis, fatty development hepatic gluconeogenesis using isolated perfusedrat liver. (79% fat, 19% protein, 2% carbohydrates in Kcal%) wasadministered rats over four weeks three conditions: hypercaloric; isocaloric andhypocaloric (energy reduction 20%). Fasting blood levels total fat liverwere higher all rats. Oral tolerance was impaired andhypercaloric groups, although insulin sensitivity wasn´t altered. also causedmarked metabolic alterations: rate from lactate a reducedcapacity catabolize alanine, latter effect more intense hypocaloric condition. Weconcluded that, even when used for weight loss, our data imply that they canpotentially cause harmful consequences
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ژورنال
عنوان ژورنال: Arquivos do Mudi
سال: 2023
ISSN: ['1980-959X']
DOI: https://doi.org/10.4025/arqmudi.v27iespecial.68207